Relationship Between Health Status and Systemic Inflammation

Relationship Between Health Status and Systemic Inflammation Participants The Tianjin Chronic Low-grade Systemic Inflammation and Health (TCLSIH or TCLSIHealth) cohort study is a observational study was based on annual health examinations conducted in Tianjin Medical University General Hospital Health Management Center in Tianjin, China[13, 14], and focused on the relationship between chronic low-grade systemic inflammation and the health status. Participants, who had received health examinations, including medical examinations, such as blood tests, abdominal ultrasonography, anthropometric parameters (height and body weight) etc., and had completed questionnaires regarding their smoking and drinking habits and disease history over the course of January 2007 to December 2015, were recruited. Moreover, a detailed lifestyle questionnaire covering economic level, marital status, employment status, educational levels, physical activity, sleep habits, dietary habits, overall computer/mobile device usage times, television time, history of prior infections, and u se of medicines as well as physical performance tests were administered to randomly selected subjects from this population since May 2013. The protocol of the study was approved by the Institutional Review Board of Tianjin Medical University, and written informed consent was obtained from each participant. A total of XXXX subjects participated in this study. However, participants who had a history of type 1 diabetes mellitus, or who missed information on hs-CRP, IMT or plaques were not included in the present study. After excluding those subjects, the final cross-sectional analysis population comprised 8000 participants including 6009 subjects with normal blood glucose metabolic status, 1428 subjects with pre-diabetes and 563 subjects with diabetes. Assessment of T2DM Fasting blood glucose (FBG) was measured by the glucose oxidase method. Blood samples for analysis of HbA1c were mixed with ethylenediaminetetraacetic acid (as an anticoagulant) before testing. HbA1c separation and quantification were performed using a high-performance liquid chromatography analyser (HLC-723 G8; Tosoh, Tokyo, Japan) with intra- and interassay coefficients of variation of